the present study conducted with the aim of evaluating the efficacy of laser photobiomodulation on orthodontic tooth movement in children. Method: In present systematic review and meta-analysis, information about orthodontic tooth movement in children in all articles published until the end of July 2023 through searching in databases PubMed, Scopus, Science Direct, ISI, Web of Knowledge, Elsevier, Wiley, and Embase and Google Scholar search engine were extracted using keywords and their combinations by two trained researchers independently. Data analysis was done using the fixed effects model in meta-analysis, by STATA (version 17); P-value less than 0.05 was considered significant. Result: A total of eight studies were included in the meta-analysis process. Laser Photobiomodulation significantly increased the acceleration of orthodontic tooth movement compared to control group (MD: 0.29, 95% CI: 0.25, 0.34 (p<0.01). Conclusion: low-level laser therapy is an effective approach for accelerating tooth mobility in orthodontic treatments.