Background: This study was conducted for evaluating the therapeutic efficacy of curcumin in the management of oral squamous cell carcinoma. Material and methods: SCC-25 cells were maintained in Dulbecco’s modified Eagle’s medium, enriched with 10% fetal bovine serum (FBS), 100 IU/ml penicillin, and 100 μg/ml streptomycin, at a temperature of 37°C in a humidified environment consisting of 95% air and 5% CO2. After treatment with curcumin at concentrations of 0, 10 µmol/L, 20 µmol/L, 40 µmol/L and 80 µmol/L for 24 hours, concentration of 0, 10 µmol/L, 20 µmol/L, 40 µmol/L and 80 µmol/L for 48 hours. The cells were fixed on ice for 30 minutes using 100% cold ethanol, subsequently washed, and resuspended in a staining buffer (BD, USA) containing 0.05 mg/ml propidium iodide and RNase A for 30 minutes at room temperature in the absence of light. SCC-25 cells were treated with or without curcumin, and Western blot analyses were conducted. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results: The inhibition rate at 24 hours at concentration of 10 µmol/L, 20 µmol/L, 40 µmol/L and 80 µmol/L was 21 percent, 38 percent, 49 percent and 53 percent respectively. The inhibition rate at 48 hours at concentration of 10 µmol/L, 20 µmol/L, 40 µmol/L and 80 µmol/L was 43 percent, 59 percent, 66 percent and 71 percent respectively. Curcumin demonstrates an inhibitory effect on the invasion of SCC-25 cells. The cells were treated with curcumin for a duration of 24 hours at varying concentrations of 0, 10, and 40 μmol/L. Mean cell number at concentration of 0, 10, and 40 μmol/L was 63.2, 55.7 and 41.9 respectively. Conclusion: The findings from our research indicated that curcumin effectively inhibited cell number and invasion of SCC-25 cells. These results imply that curcumin influences the proliferation and invasive behaviour of SCC-25 cells.