ISSN : 2663-2187

EVALUATION OF BIOCOMPATIBLE SOLUBLE OCULAR INSERTS FOR EFFECTIVE GLAUCOMA MANAGEMENT

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Sakshi Yadav, Aman Yadav, Dr. Manoj Kumar Mishra
» doi: 10.48047/AFJBS.6.15.2024.12742-12759

Abstract

This study investigates the formulation, characterization, and stability of ocular inserts containing Timolol Maleate, aiming to enhance ocular drug delivery. Ocular inserts were developed using various polymers, and their physical and chemical properties were meticulously evaluated. Thickness, folding endurance, surface pH, weight uniformity, and drug content were measured across multiple batches (FE-1 to FE-5), demonstrating consistency and reliability in the formulations. The drug release profile exhibited a sustained release over four weeks, with cumulative drug release assessed at different time intervals. Additionally, the inserts maintained their physical appearance and stability over a three-month study period under controlled storage conditions, confirming their potential for long-term use in ophthalmic applications. The findings indicate that these ocular inserts are promising candidates for effective ocular drug delivery, with the potential for further optimization and exploration of additional therapeutic applications.

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