In the world, rice (Oryza sativa L.) is an essential crop that provides food for more than half of the population. India's Northern Indian Plain is one of the country's principal rice-producing regions. However, brown spot disease, which is brought on by Bipolaris oryzae, is one of the most destructive diseases that affect rice farming. By using effective management approaches, including fungicides, resistant cultivars, biological procedures, and cultural strategies, crop losses caused by brown spot disease can be mitigated. This study presents a comprehensive examination of five chemical fungicides and one biocontrol agent to prevent the prevalence of brown spot disease among three rice cultivars i.e. BPT 5204, Swarna mansuri and Kasturi. Results of this study reveals, the disease found most severe in BPT 5204, and other rice varieties like Swarna mansuri and Kasturi displayed less susceptibility towards brown spot disease. To mitigate the impact of brown spot disease foliar application of Trifloxystrobin 25% + Tebuconazole@ 0.4 g L-1 at 45 days will become most beneficial and increase rice yield at 53.32, 76.9 and 79.66% increase over control in all tested varieties i.e. V1, V2 and V3 respectively. After that, foliar application of Definiconazole@ 1.0 ml L-1 and Propiconazole@ 1.0 ml L-1 also displayed a good performance against Bipolaris oryzae. It is crucial for farmers to adopt good rice cultivar and better control technique to major diseases. This research will assist farmers in minimizing losses due to brown spot disease and improving rice production levels.