Background: Orthodontic treatment often involves bonding brackets to tooth enamel, which may lead to colour changes. This study aimed to evaluate the extent of enamel colour changes associated with orthodontic bonding procedures and to assess the effectiveness of various cleaning methods in restoring original tooth colour. Materials and Methods: Sixty extracted human premolars were randomly divided into three groups (n=20 each). Colour measurements were taken using a spectrophotometer before bonding, immediately after bonding, and after debonding followed by cleaning. Group A underwent conventional acid-etching and bonding, Group B used a self-etching primer, and Group C utilized a resin-modified glass ionomer cement. Cleaning methods included pumice polishing, carbide bur, and enamel microabrasion. Results: Significant colour changes (ΔE) were observed in all groups after bonding (p<0.001). Group A showed the highest mean ΔE value of 3.82 ± 0.76, followed by Group B (3.24 ± 0.62) and Group C (2.97 ± 0.58). Post-debonding, enamel microabrasion was most effective in restoring original tooth colour, with mean ΔE values of 1.12 ± 0.31, 0.98 ± 0.27, and 0.87 ± 0.23 for Groups A, B, and C, respectively.