Background-Ghrelin, a peptide hormone known for its influence on the immune system, was the focus of this study. The primary objective was to check the levels of ghrelin in the plasma of individuals with chronic periodontitis and explore potential associations between ghrelin and periodontal parameters. Methodology- This study comprised 20 individuals with chronic periodontitis (CP) and a control group of periodontally healthy individuals (C). Various periodontal parameters were documented, and saliva samples were collected to analyze ghrelin levels. Results- A significant improvement was observed in both the groups (p<0.05). However, we did not identify a direct correlation between the levels of ghrelin and periodontal parameters. Our findings suggest an elevation in ghrelin levels among individuals with chronic periodontitis. Conclusion- Moreover, investigations involving larger cohorts, encompassing the analysis of ghrelin levels in oral tissues and fluids are necessary to validate the potential involvement of ghrelin in periodontitis