Hypothyroidism has been referred to as a multi-systemic disease and its impact on renal function is currently being understood. To evaluate whether hyperthyroidism affects renal functioning, the study has defined fluctuations in the estimated glomerular filtration rate (eGFR), an important indicator of kidney functioning. It aimed to compare the eGFR observed under hyperthyroid states with that of euthyroid controls, thus ascertaining the degree of renal performance relative to eGFR in hyperthyroidism. This study followed a cross-suit design approach and enrolled 120 study propositions including 60 hyperthyroid and 60 euthyroid matched based on sex, age, and BMI. eGFR differences between groups were analyzed and were found to be significant (p<0.01) with hyperthyroid having a mean eGFR of 78.6±15.3mL/min/1.73m² lower than one for the control group, 91.2±12.5mL/min/1.73m². Results indicate that hyperthyroidism could be a risk factor for the Impairment of kidney function via gradual and multifactorial alteration. Employing the dynamic approach to thyroid function, the present research provides new data on the correlation between thyroid and renal dysfunction, its clinically important aspects, and the rationale for the renal examination of hyperthyroid patients. The results are therefore of statistical significance if taken clinically and indicating the importance of the results.