The four plants were selected for this research namely Cassia auriculata, Glycyrrhiza glabra, Piper longum and Syzygium aromaticum based on ethno botanical information, literature, references and therapeutic significance. These weremostly reported for anti-diabetic, anti- cancer, anti-inflammatory activities and for several other therapeutic indications. Though several researchers also reported antimicrobial activities for these plants, most of these plants have not been fully studied for their antimicrobial potential and exploited as antimicrobials, especially as drug potentiators, or resistance modifying agents, or synergistic agents. In this article, antimicrobial activities of selected Indian medicinal plants has been evaluated.