The skin is recognized as the largest organ in the body. It is the essential component that guards tissues from microbial infection, UV radiation, and very high or low temperatures. In the present research work on wound healing, the leaves of Ehretia acuminata was studied for wound healing in incision and excision models in rats. The phytochemical screening of hydro alcoholic extracts confirms the presence of tannins, saponin glycosides, cardiac glycosides, flavonoids, steroids, proteins, carbohydrates, and alkaloids. The hydro alcoholic extract was administered via topical application to the rats. The wound healing potential was evaluated using various parameters, such as breaking strength, wound contraction, and the time needed for complete epithelialization of the wound area. This suggests that the extract may increase protein cross-linking and encourage collagen formation at the cellular level. The results of our in-vivo investigation show that hydro alcoholic crude extracts from the leaves of Ehretia acuminata favorably influence albino rats ability to repair wounds using different in-vivo wound healing models and substantially decreased lesion area