This comprehensive study utilizes an integrated approach, merging network pharmacology, molecular docking, and systems biology analyses, to uncover the anti-inflammatory potential of compounds derived from Phyllanthus niruri. Targets associated with Phyllanthus niruri were identified through various databases, and subsequent filtering using ADME analysis ensured a focus on targets with favorable drug likeness and oral bioavailability. Predicted targets for the filtered compounds were identified using Swiss Target Prediction and the Similarity Ensemble Approach (SEA)