Abstract Background and Study Aim: The promotion of sports has become a national and human necessity, considering it one of the most important means of preparing and developing all members of society to face the civilizational challenges that require an increase in physical and health capacities. The objective of this study was to investigate the influence of social stigma on the self-esteem and physical fitness levels of overweight female students engaged in health and weight loss endeavors. Material and Methods: The study employed an experimental design with both experimental and control groups, employing pre-test and post-test measurements. It focused on obese female students aged 19 to 22 at Imam Abdulrahman Bin Faisal University, Saudi Arabia, totaling 90 participants. Selection criteria included no prior sports programs or weight loss operations. The primary sample comprised 12 participants, ensuring homogeneity in growth variables and other relevant factors. Anthropometric measurements were utilized to assess obesity levels and body fat percentage, using stable and valid equations. Results: Significant statistical differences were observed between pre- and post-measurements of physical fitness, favoring the post-measurements among obese female students. This indicates that the physical exercises led to improvements in physical fitness levels over time. Similar to physical fitness, significant statistical differences were found between pre- and post-measurements of weight reduction, favoring the post-measurements among obese female students. The exercises had a positive impact on weight reduction efforts, resulting in measurable changes in body weight and fat percentage. The sample of obese female students exhibited a high level of positional criticality, as indicated by the results of the positional critical scale. This suggests that these individuals faced challenges and discomfort related to their body positioning and movement. Conclusions: The performance level of physical exercises among the research sample of obese female students was found to be moderate. While participants engaged in physical activity, their overall performance levels were not exceptionally high. Higher levels of positional criticality were associated with lower performance outcomes in physical exercises among female students. This indicates that individuals who experienced greater discomfort and challenges in their body positioning had lower performance levels during physical exercises.