Thiadiazole heterocycles are best known to offer a variety of biological activities as therapeutic sensitive agents in medicinal chemistry. Thiadiazole nucleus can be found in certain bacteria thiazolyl peptide antibiotics. In this review we have discussed the applications of imidazothiadiazoles in different fields. Based on concerns related to imidazothiadiazoles, their structural features, anticonvulsant activities, bactericidal, antifungal, antimycobacterial, anticancer, anti-inflammatory, antihypertensive, and anti-HIV properties, and the molecular targets they attach have also been surveyed. We believe that this research will motivate and help researchers to design more potent imidazothiadiazole derivatives for targeted protein inhibitor discovery. This review collected valuable information for the synthesis and pharmacological significance of imidazothiadiazoles and is considered to plot an imperative focus for researchers to work on.