ISSN : 2663-2187

Fabrication and Characterization of Lacosamide Mouth Dissolving Films using Solvent Casting Technique

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Khanderao Rajaram Jadhav, Vrushali Santosh Gangurde*, Pradnya Hemant Kapse, Rishikesh Shankar Bachhav
ยป doi: 10.48047/AFJBS.6.13.2024. 548-564

Abstract

The pharmaceutical market is dominated by oral dosage forms, which constitute approximately 52% of total dosage forms. Traditional forms such as tablets and capsules present various challenges, including dosing inaccuracies and potential loss of active ingredients. Mouth dissolving films (MDF), have emerged as a promising alternative, enhancing compliance and ensuring precise dosing. This study focuses on the preparation and estimation of Lacosamide mouth dissolving films using the solvent casting technique. Lacosamide, an anticonvulsant with a unique dual mode of action, offers advantages in rapid onset of action and improved bioavailability when delivered through MDF. The films were prepared using hydroxypropyl methyl cellulose (HPMC) as the polymer matrix and polyethylene glycol (PEG 400) as plasticizer. Various formulations were developed and assessed for their physical and mechanical properties, drug content uniformity, disintegration time, in vitro release, and surface morphology. The optimized formulation (F3) demonstrated excellent results with rapid disintegration (within 24 seconds), high folding endurance, and nearly complete drug release i.e., 98% within three minutes. Accelerated stability studies confirmed the formulation's stability over three months. This innovative approach underscores the potential of MDF for efficient and effective Lacosamide delivery, enhancing patient compliance and therapeutic efficacy.

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