Background: Poor performance will result in poor service, patients feel uncomfortable and dissatisfied. Performance in this case is closely related to the workload and work stress of nurses in providing health services. Objective: This study aims to determine the factors that influence work fatigue (burnout) on the performance of nurses in nursing care in the inpatient department of Hasanuddin University Hospital.. Method: The research design uses a cross-sectional study approach. Hasanuddin University Hospital Makassar in December 2023. The population in this study were all nurses with status who worked at Hasanuddin University Hospital Makassar with a total sample of 66 nurses. The sampling method is total sampling. The data collection instrument uses a structured questionnaire. Bivariate analysis was carried out using the chi-square test and then continued with multivariate analysis. Presentation of data in tabular form is accompanied by narration.