Allium Sativum loaded nanosponges were prepared successfully that belongs to class II of Biopharmaceutical Classification System, that shows that it has low permeability and high solubility. Nanosponges shows sustained release and controlled release property in formulation so as to enhance the effect of allium sativum for the management of rheumatoid arthritis for longer duration. The formulation of allium sativum loaded nanosponges were done by emulsion solvent evaporation method, in which two phases were prepared i.e., the organic phase and the aqueous phase that is further mixed at 1000 rpm for production of nanosponges. The formulated nanosponges were evaluated with particle size, drug entrapment, percentage drug release and percentage yield, by which optimized formulation was obtained using optimization technique Box Behnken Design. The optimized formulation was subjected to SEM analysis and FT-IR study. The particle size of the optimized formulation was obtained as 290.5 nm, with 80.1% drug release, 86% drug entrapment, and 82.58% yield.