Worldwide prevalence of the psoriasis is 2 – 3 %. Clobetasol propionate (CP) is a super potent corticosteroid having immunosuppressive, anti-inflammatory and antiproliferative activity. This study was intended to formulate and evaluate babchi oil nanoemulsion (NE) loadedgel containing CP and Salicylic acid (SA) for psoriasis. CP having a poor permeability to skin so, to enhance its permeability it was incorporated into the oil and formulated and evaluated a nanoemulsion gel.Another important objective regarding this research is to selection of natural oil having anti-psoriatic activity with this drug may be substantially reduce the side effects of CP and enhance anti-psoriatic activity in parallel ways with the CP. Aqueous phase titration method was used to formulate a nanoemulsion using oil phase, surfactant, co-surfactant, & aqueous phase as Babchi Oil (BO), Tween 80, Transcutol P, and distilled water respectively. Pseudo ternary phase diagram was constructed and different formulation composition were selected from phase diagram. Selected formulations were subjected to in vitro permeation studies, globule size distribution average globule size and zeta potential, pH, viscosity, refractive index (RI), conductivity and transmission electron microscopy (TEM). Optimized nanoemulsion loaded into HPMC hydrogel and salicylic acid was incorporated.The optimized nanoemulsion formulation (NE14) exhibited in vitro permeation (44.05 %), globule size distribution (0.124), average globule size (236.67 nm), zeta potential (-20 mV), pH (5.68 ± 0.124), viscosity (14.86 ± 1.05 cP), RI (1.417 ± 0.012), conductivity (53 ± 5.38 μs/cm) and TEM (). Optimized NE loaded into the HPMC gel containing 5% SA. Further, gel evaluation carried out for pH, viscosity, spreadability extrudability and permeation study, compared with in vitro permeation of nanoemulsion. The results were found to be pH (6.29 ± 0.173), viscosity (4438.69 ± 53.17 cP), spreadability (1.23 times more spreadable than marketed formulation), extrudability (almost similar to marketed formulation) and in vitro permeation (97.59 % permeation found in comparison to NE14). On behalf of above mentioned results it was concluded that optimized CP loaded nanoemulsion gel might be an alternative approach for the topical delivery.