ISSN : 2663-2187

FORMULATION AND EVALUATION OF DIVALPROEX SODIUM CONTROL RELEASE FOR ORAL DELEIVERY

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Makwana Rajeshree, Mayurkumar H. Agravat, Harsh Chunara, Arpita Patel
» doi: 10.48047/AFJBS.6.7.2024.4596-4614

Abstract

The objectives of this research work are to formulation and evaluation of divalproex sodium control release for oral delivery it may decrease the dosage frequency, increase the patient compliance and minimize the dose dumping. Osmotic tablet is prepared as controlled porosity osmotic tablet which is prepared by adopting wet granulation method. In this research work we had taken the preliminary batches for selection of osmogen and pore forming agent. Sodium chloride, as an osmogen and mannitol as pore forming agent. Different batches were prepared with different concentration of osmogene to find out thr optimized batches total fout coating solutions were prepared and evaluation of them were selected for their further formulation process all evaluation parameters were evaluated for determination of optimized batch and after stability study the prepared batch of osmotic tablet was compared with marketed formulations Based on all results, T5C2 Batch had gives maximum release 99.% at 24hr it gives satisfactory results. From all the results we had conclude that by preparing osmotic tablet it may give sustained release of drug over the period of time and also gives patient compliance.

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