In present study,leading objective is to prepared and evaluate transdermal cream of curcumin by using three absorption bases namely Shata dhutaghrita, mauhaoil and shea butter along with α- bisabololas permeability enhancer. Total six batches were prepared (F0-F5) and estimated for physical form, drug content, pH, Spreadability, In vitro diffusion and ex-vivo permeability studies in associationwith marketed formulation. Study showed that creamswere bright yellow in color. In vitro release analysis reveals that the F5 batch hadhigher drug release than the marketed formulation. Therefore, F5 batch is an optimized batch.The ex vivo permeability showed that F5 formulation is more permeable than marketed formulation. The release kinetic datashows that n exponent value of F5 batch is greater than 0.9 which reveals that release kinetic of F5 batch follows supercase II transport drug release mechanism.