The term "hepatic disease" refers to a broad category of conditions that affect the human liver's tissues, structures, and cells. The liver performs a great deal of vital processes, therefore there are many opportunities for anything to go wrong. Inflammation is one of the most frequent causes of liver illness and is frequently brought on by alcohol abuse, a bad diet, or even malnourishment. The most significant health concern that affects the drug control board, the pharmaceutical industry, and medical professionals is medication-induced liver damage or dysfunction. The United States Acute Liver Failure Study Group states that over half of cases of acute liver failure are due to drug-induced liver injury, which includes paracetamol overdose-induced hepatotoxicity. The present paper deals with the formulation of polyherbal tablet containing hydro-alcoholic extract of Abutilon indicum Leaves and Phyllanthus niruri Fruits. The formulated tablet was evaluated and screened for Hepatoprotective activity against paracetamol induced liver toxicity in albino rats. The results indicate that prepared polyherbal tablet showed significant hepatoprotective activity as compared to the hepatotoxic control.