Materials Adapalene was gifted from Cipla Pharmaceuticals, Ahmedabad, India. Benzoyl Peroxide was gifted from Sun Pharmaceuticals, Hosur, India. Remaining all ingredients was purchased from Himedia laboratories, Hyderabad. PREPARATION OF NIOSOMAL GEL FORMULATIONS Preparation of Adapalene niosomal gel Carbopol 940 gel bases are prepared by homogenizing 1 % (w/w) carbopol dispersion in sufficient water using a magnetic stirrer for 30 minutes and leaving it to equilibrate for 24 hours. After that, pH is adjusted to 4.5 – 6.5 with Triethanolamine (Saleem M.A, et al.,, 2010). The Adapalene loaded niosomes is added to the prepared plain gel base during the stirring process and the step is completed as mentioned for carbopol plain gel bases. EVALUATION OF NIOSOMAL GEL FORMULATIONS The prepared Adapalene niosomal gel was subjected for various in vitro evaluation tests such as drug content analysis, pH measurements, rheological studies, in vitro drug release and stability studies.