Introduction: Preterm birth is a major health problem and leading cause of neonatal morbidity and mortality with high incidence all over the world. Preterm birth is the most common complication associated with multiple pregnancies. Multiple pregnancies have increased over the past decade due to the use of fertility drugs. Objective: To determine the frequency of preterm birth in multiple pregnancies Study Design: Cross sectional study. Setting: Department of Obstetrics & Gynecology women medical and dental college abbottabad Duration of Study: This study was conducted from 10th May 2021 to 10th November 2022. Subjects and Methods: A total of 196 pregnant women with multiple pregnancies were included in the study. A detailed explanation about the participation in the study was given to the patient and informed consent was obtained explaining the benefits of the study. Basic demographics like age, gestational age and weight, BMI along with the other data like number of fetuses, gender of fetuses, chronicity, amnionicity, mode of delivery, duration of labor, past history of preterm labor was recorded. Results: Age range in this study was from 18 to 35 years with mean age of 28.469±3.05 years, mean gestational age 31.250±1.98 weeks, mean Duration of labour 11.413±4.23 hours, mean Birth weight 2.579±0.27 Kg, mean Cervical length 25.459±3.45 mm and mean BMI was 25.464±1.47 Kg/m2. Preterm Birth was seen in 33.2% patients. Conclusion: In conclusion, preterm delivery remains the most serious complication of multiple pregnancies.