This study examined the gender-specific behavioral and emotional challenges faced by children aged 6-12 diagnosed with depression, with a primary focus on understanding these differences to inform the development of gender-sensitive interventions. A stratified random sample of 150 children from schools in Agra, India, was assessed using a self-developed scale designed to measure behavioral and emotional difficulties. T-tests were conducted to assess the differences between boys and girls. The results indicated that boys experienced significantly higher levels of behavioral problems (mean = 45.2, t = 4.28, p < 0.001), predominantly manifested through externalizing behaviors such as aggression and defiance. In contrast, girls showed more significant emotional challenges (mean = 43.7, t = 3.78, p < 0.01), marked by social withdrawal, sadness, and internalizing distress. The comparative analysis revealed statistically significant gender-based differences in the expression of depressive symptoms, underscoring the distinct emotional and behavioral challenges that boys and girls face. These findings highlight the critical need for gender-sensitive diagnostic tools and targeted interventions. Approaches aimed at enhancing emotional regulation in boys and fostering emotional resilience in girls could lead to improved mental health outcomes. This study emphasizes the importance of collaborative efforts among caregivers, educators, and mental health professionals to develop comprehensive, tailored interventions that address the long-term impact of childhood depression.