This study aimed to investigate the histopathological features of hepatic cirrhosis in camels from the El Oued region of Algeria. Liver samples were collected from camels at a regulated slaughterhouse and processed for histological examination. The tissues were fixed, embedded in paraffin, and sectioned for staining with hematoxylin and eosin (H&E) and Azan trichrome. Histological analysis revealed significant degenerative changes in hepatocytes, characterized by both microvesicular and macrovesicular steatosis, along with infiltration by inflammatory cells. Moderate fibrosis was observed extending into the liver parenchyma, accompanied by chronic liver damage marked by expansion of the portal areas and fibrous tissue overlay. Typical features of cirrhosis, such as disruption of the lobular structure, formation of regenerative nodules, and intra-lobular proliferation of connective tissue, were prominent. Additionally, hypertrophied hepatocytes were identified, either grouped or as isolated cells. These findings provide valuable insights into the pathological progression of hepatic cirrhosis in camels, highlighting the severe morpho-functional alterations associated with this condition.