Diabetes is a metabolic disorder marked by chronic hyperglycemia and oxidative stress, leading to severe health complications. In search of alternative treatments, researchers are investigating medicinal plants with unstudied therapeutic potential, Suaeda mollis is one such plant that remains insufficiently explored. This study aimed to assess the antidiabetic and antioxidant properties of its aqueous leaf extract (AES) in both healthy and streptozotocin-induced diabetic rats.