Phyllanthus amarus Schum.& Thonn., is globally distributed herbs known for its several therapeutic potentials. This species has a long history of use in the traditional system of medicine for over 2000 years owing to its wide array of secondary metabolites that confer significant medicinal attributes.(1) The present study was carried out to identify the phytochemicals present in the ethanol extract of Phyllanthus amarus Schum.& Thonn. Preliminary phytochemical screening of extracts of this species revealed the presence of proteins, alkaloids, phenolic compounds, saponins, amino acids, flavonoids and tannins. Extracts were subjected to GC-MS analysis which shows presence of phytochemicals viz palmitic acid, 2,6-dihexadecanoate, 1-methylethyl ester, methanosulfonic acid, ethyl ester, tetradecanoic acid, polyphenols, eupalitin, Epicatechin etc which has significant important in human life.