The spread of Zika virus infection in India has become a serious public health concern due to its associationwith birth defects and neurological disorders.The development of an effective vaccine to prevent viral infection is urgently needed.In this study, epitope-based peptide vaccine components based on the Zika virus envelope protein were developed using the reverse vaccinology method.The envelope protein was examined for cytotoxic T lymphocyte (CTL) epitopes using immunoinformaticstools.Common epitopes predicted by variousmethods were chosen and evaluated for immunogenicity score, toxicity, antigenicity,and allergenicityassessment as well as human homology.Four potent CTL epitopes were identified as DTAWDFGSV, SIQPENLEY, GTVTVEVQY, and MMLELDPPF