Objectives To assess the difference in C-MET receptor immunohistochemistry expression between normal and malignant colonic mucosa. To relate the C MET expression in CRC cases with various clinico-pathologic parameters. Materials and Methods An analytical, cross-sectional, retrospective comparative study was conducted. The study took place from August 2020 to August 2021 at the Pathology Department of Peshawar Medical College (PMC). 53 CRC case blocks that were formalin-fixed, paraffin-embedded (FFPE) were selected. Slides were examined histopathologically, and the C-MET receptor was assessed by immunohistochemistry. Statistical analysis was carried out using the Statistical Package for Social Sciences (SPSS) version 20.0. For categorical variables, Fisher exact and Chi-Square tests were run. Results Conclusion Keywords In contrast to the normal intestinal mucosa, which only exhibited high C MET expression in 28.8% of cases, the majority of tumor cases (60.37%) exhibited high C-MET expression. The difference being statiscally significant <0.0001. Regarding age, gender, laterality, grade, or stage of the tumor, there was no statistically significant variation in C-MET expressions. C-MET expression and tumor histologic subtypes, however, were statistically significantly correlated. The presence of C-MET overexpression in colorectal carcinoma cases relative to normal colonic mucosa supports the idea that C-MET plays a pathogenic role in colorectal cancer in our group. For CRC subtypes and the lack of lymph node metastasis (N0), C-MET overexpression was statistically significant. C-MET demonstrated a distinct pattern of elevated expression in correlation with increased Tumor Invasion (T3, T4), though not statistically significant. C-MET may serve as drug target.