Colorectal carcinoma is the third most commonly diagnosed malignancy and the fourth leading cause of cancer death in the world. The aim of present study is to evaluate Galectin-3 expression and tumor immune response as evaluated by CD8 expression in series of colorectal tumors obtained from Egyptian patients and correlate them with different clinicopathological variables. For this retrospective study, 50 formalin fixed paraffin embedded sample blocks of Colorectal carcinoma and 20 from normal colonic mucosa from patients subjected to colectomy in National Cancer Institute between 2011 and 2015 were enrolled. The 70 colorectal samples were stained with Hematoxylin and Eosin for routine histopathological evaluation and Immunohistochemical staining by Galectin-3 antibody and CD8 antibody. Current study showed significant association between Galectin-3 overexpression and colorectal carcinoma as it was expressed in 92% (46/50) of cases of colorectal carcinoma and in 25% (5/20) of colorectal non-tumorous lesions. Also there was statistically significant correlation between increased Galectin-3 expression and increasing tumor stage, lymphovascular invasion and metastasis. Also between increased CD8 immune cells density and low stage carcinomas. so Galectin-3 expression on tumor cells has considerable importance to predicting tumor invasiveness and CD8 immune cells density assess patient immune response against tumor cells