This study investigates the effectiveness of Boscia plant leaf (BSL) extract in treating melanoma skin cancer. The leaf of the Boscia plant was extracted using ethanol, and various concentrations of BSL were tested. The P values of five concentrations were obtained as P<0.0001, P<0.002, P<0.002, P<0.001, and P<0.0033, indicating significant cytotoxic effects on the tested samples. The research suggests that further soaking of the sample extract during an incubation period exceeding 48 hours could yield more substantial results. Additionally, the impact of the culture medium varied during the growth time. Furthermore, the study explored the effect of antioxidants on the liver, showing promising results that warrant further investigation.