Curcumin is an inherent component present in the spice turmeric. Renowned for its vibrant yellow hue, this subject has been thoroughly examined for its possible advantages to one's well-being. Curcumin demonstrates potent anti inflammatory and antioxidant characteristics, which could aid in the treatment of several health disorders. Although curcumin has advantages, it has limited bioavailability. Hence, a nanoemulsion formulation of curcumin was synthesised and subsequently assessed for its potential in conducting antioxidant and antibacterial investigations. In the current research work accelerated stability tests assessed the changes in the quality of medication over time. From month 1 to month 4, the CUNL (curcumin nanoemulsion) observed an upward trend in zeta potential, particle size, polydispersity index, and viscosity, while the pH decreased. The research further revealed that encapsulation significantly decreased its scavenging activity, especially at low doses (< parts per million). However, the scavenging activity of both samples was determined to be comparable when the concentration ranged from 18 to 23 parts per million (ppm). In addition to this, CUNL was found to be highly efficient against Staphylococcus aureus (ATCC-6538), Streptococcus pyogenes (SF370), Staphylococcus epidermidis (ATCC 12228), Corynebacterium minutissimum (DSM 7174), and Cutibacterium acnes NCTC 737. The highest level of inhibition was seen for Cutibacterium acnes (17.2 ± 0.1), followed by Staphylococcus epidermidis (18.6 ± 0.2), Corynebacterium minutissimum (12.4 ± 0.1), Staphylococcus aureus (11.6 ± 0.2), and Streptococcus pyogenes (10.7 ± 0.2) as determined by CUNL. The results clearly showed the effectiveness of the curcumin nanoemulsion in killing microorganisms.