Worldwide, 1,914,916 people got infection with COVID-19 in the middle of April 2020, with 123, 010 losses and 501,758 survived, according to the World Health Organization (WHO). Researchers have discovered that after a coronavirus infection, certain signaling pathways can impact how the immune system's cells work. These pathways include the toll-like receptor as well as the retinoic acid-inducible gene-I-like receptor signaling pathways. As a result, these cells can produce a variety of cytokines associated with the 17-receptor, which can further impair both the innate in addition to adaptive immune systems. PURPOSE: to examine the impact of dry cupping therapy on T-Lymphocyte, IL-6, IgA, IgM and IgG in patients with post-COVID-19. DESIGN: Patients were assigned randomly into two equal groups by randomized controlled trial. SETTING: Patients with post Covid-19 from Outpatient Clinic Shobra General Hospital, Cairo governate, Ministry of Health,Egypt. SUBJECTS: seventy- six patients (21 to 66 years old) previously infected with SARS-CoV-2. METHODS: Over the course of eight weeks, patients were divided into two equal groups utilizing a computer-generated block randomization program. Group "A" received dry cupping therapy as well as traditional medical treatment, while group "B" received the same traditional medical treatment program. The patients' pre- and post-treatment evaluations were performed using body weight and height scale for measuring weight and height then calculating BMI, Flow Cytometry device for detecting physical and chemical characteristics of cells or particles, Automatic biochemistry analyzer for cytokine detection and Semi- Automatic protein analyzer for IgA, IgM, IgG detection. RESULTS: mixed design MANOVA comparisons showed that all variables in both groups differed significantly between before- and following treatment, with a p-value less than 0.05. After the therapy, the analysis revealed that the study group had statistically significant improvements over the control group (p-value <0.05) when comparing the two groups. CONCLUSION: Dry cupping has a positive effect on the immune system, and inflammatory markers in post COVID-19 patient