Water scarcity and contamination present significant challenges to global public health and environmental sustainability. Conventional water purification methods, while effective to some extent, often fall short in addressing emerging pollutants and ensuring long-term sustainability. This research explores innovative approaches to water purification by integrating advanced technologies, including nanotechnology, advanced oxidation processes (AOPs), and bioremediation. Through a comparative analysis of these technologies, we evaluate their effectiveness in pollutant removal, efficiency in terms of energy and resource consumption, and overall sustainability. Real-world case studies are examined to provide practical insights into the scalability and application of these technologies in both urban and rural contexts. The findings indicate that while each technology offers unique advantages, a hybrid approach that combines these technologies can provide a more comprehensive solution to water purification challenges. This study contributes to the development of sustainable clean water solutions and offers recommendations for policymakers, researchers, and practitioners aiming to improve water quality and accessibility.