Abstract:-Background: Nephrotic syndrome is a common chronic kidney disorder in early childhood characterized by proteinuria, hypoalbuminemia, hyperlipidemia and generalized edema. Repeated infections frequently complicate its progression. Case Presentation: A 4-year-old male came with complain of recurrent cough, cold, and progressive edema. Decrease frequency of urination, Itching over the body. Following an unsuccessful course of allopathic treatment, the patient underwent Unani therapy comprising oral medications. The patient was managed unani formulations aimed at diuresis, immune support, and hepatic strengthening. Symptomatic improvement was noted with reduction in edema, improved appetite, decreased respiratory symptoms, and better overall well-being. Conclusion: This case highlights the potential supportive value of Unani medicine alongside standard care in managing pediatric nephrotic syndrome, especially in children experiencing recurrent infections. Further controlled trials are necessary to explore the findings.