ISSN : 2663-2187

Investigating the Impact of Pregnancy-Related Hypertension on Renal and Hepatic Function: A Comprehensive Cross-Sectional Analysis

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Esha Babar Baig, Dr Muhammad Saeed, AmnaTehreem, Mirza Umer Baig, Anum Ijaz, Manahid Tariq, Ayesha Javed Wattoo, Javeria Sharif, Dr.Arsalan Ali, Muhammad Aqib Khalil, Dr Farah Naz Tahir
» doi: 10.48047/AFJBS.6.15.2024.9050-9057

Abstract

Background and Objective: Hypertensive disorders during pregnancy (HDP) especially pregnancy-related hypertension (PRH) are quite dangerous as they have adverse effects on both the mother and fetus and are often associated with the development of acute renal failure (AKI) and acute liver injury. Thus, the purpose of the current study was to evaluate kidney and liver function, using renal (creatinine, urea) and hepatic (AST, ALT) parameters in women suffering from PRH, in comparison with healthy pregnant females. Methodology: The cross-sectional study was conducted at the Department of Obstetrics and Gynaecology department Central Park Teaching Hospital, Lahore, Pakistan from 27 November 2023 to 15 March 2024. A total of 90 pregnant women aged between 20 and 45 years were included in the study with three sub-groups i.e., group1-normotensive controls, group2 PRH patients who were endurance renal function tests, and group 3-PRH patients who were insulin endurance liver function tests those who were aged between 20-45. Only systolic and diastolic blood pressure, creatinine, urea, AST, and ALT were compiled and analyzed using IBM SPSS version 22 at a confidence level of 95% and a significance level of 5%. Results: The mean age of the patients enrolled in the study was 29.54 ± 6.83 years. Group 2 had creatinine (2.75 mg/dL) and urea (55.5 mg/dL) values which were higher than controls (1.2 mg/dL and 37 mg/dL, respectively, p < 0.001) (n=20). Group 3 had upper normalized values of AST (40.02 IU/L) and ALT (47.01 IU/L) compared to controls (24 IU/L and 15.22 IU/L, respectively, p < 0.001) (n=24). Systolic and diastolic blood pressure was significantly higher in PRH patients than in controls (p < 0.001). Conclusion: Previous studies confirm that PRH is characterized by abnormally high levels of creatinine and ALT suggesting that kidney and liver functions were compromised relative to normal pregnant women. If discovered and managed at the early stages, PRH may prevent adverse effects resulting in one of the worst conditions including AKI or liver failure and it may improve outcomes for both the mother and the fetus.

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