In the present study the extract from the leaves of Leucas cephalotes was used to investigate the antidiabetic activity in streptozotocin induced diabetic rats. The Ethanolic extract of Leucas cephalotes at doses of 200/400 mg/kg of body weight and profiling blood glucose levels at 0, 7,14 and 21 days using a glucometer. Biochemical parameter such as serum Bilirubin, Bilirubin direct, Bilirubin indirect, Total protein, Serum albumin and Globulin were also evaluated. Leucas cephalotes leaf extract at the tested dose levels of 200 and 400 mg/kg showed a significant reduction in blood glucose level with 150 and 122 mg/dl. When compared with diabetic control group. The observed antidiabetic activity could be associated with the phytochemicals present in the plant extract. So, results indicates that Leucas cephalotes leaves extract posses antidiabetic activity over synthetic drug.