Diabetes mellitus is a pervasive global health issue that is steadily escalating. It is projected that the global diabetic population would increase to 366 million by 2030. Discovering new antidiabetic medications from medicinal plants that have low or no adverse effects is a tough endeavor, as the currently available drugs for diabetes, such as insulin or oral hypoglycemic agents, often have one or more negative effects. The current study was conducted to examine the antidiabetic and antioxidant properties of Semecarpus anacardium (Linn.) The present investigation revealed that the leaf of the S. anacardium and Cymbopogon citratus plant exhibited the most elevated concentrations of phenolic and flavonoid components. These molecules had strong antidiabetic and antioxidant effects, comparable to the commercial antidiabetic drug metformin and the antioxidant ascorbic acid. The extract derived from Semecarpus anacardium and Cymbopogon citratus shows promise as a natural agent with antidiabetic and antioxidant properties.