Background: The dualistic nature of leptin, potentially serving as both a favorable and unfavorable prognostic factor, remains a subject of debate. This study investigates leptin expression in serous ovarian carcinomas and assesses its impact on metastasis and lymphovascular invasion in high grade serous carcinoma. Method: This study employed a cross-sectional design. Leptin expression in tissue microarrays from 77 patients with serous ovarian cancer was evaluated immunohistochemically. Paraffin-embedded tissue samples were obtained from the Wahidin Sudirohusodo Hospital, Indonesia, over the past three years. Data were analyzed using chi-square and Mann Whitney U tests. Result : The majority of patients (58.4%) were over 50 years old, and another 40.3% of patients were obese. Sixty percent of patients had metastasis, 35.1% showing lymphovascular invasion and 57.1% showing tumor necrosis. We found that leptin was consistently expressed in tumor cells of low-grade tumor, while high-grade serous carcinoma showed variable expression (p-value 0.004). Leptin analysis in high-grade tumor did not reveal a significant association with the incidence of metastasis and invasion (p-value <0.05). Conclusion: A correlation exists between tumoral leptin expression and low-grade serous carcinoma. Nevertheless, additional research on the leptin paradox within this tumor subtype is required to assess its impact on metastasis, invasion, and prognosis.