Nephropathy is one of the most common complications of the hyperthyroidism with a limited therapeutic strategy. Thus, the current study was designed to investigate the possible ameliorative potency of the glucagon like peptide agonist (liraglutide) alone or in combination with angiotensinogen converting enzyme inhibitors (Captopril). Fifty male adult Sprague Dawley rats were assigned into five equal groups ten rats each, control group, hyperthyroidism induced nephropathy (HTN) group, HTN liraglutide treated group, HTN captopril treated group, and HTN cotreated with captopril and liraglutide group. The renal function test and the gene expression for the renal fibrotic and autophagy markers were assayed. The result revealed that liraglutide alone or combined with the captopril improve renal function tests and alter the expression of the of the renal autophagic markers with outperforming effect for the combination. Taking together the administration of liraglutide alone or combined with captopril modulated the hyperthyroidism-induced nephropathy in rats via altering the expression of renal autophagy signaling pathway.