Psoriasis is an immune-mediated inflammatory skin condition affecting 2-3% of the global population, often contributing to various comorbidities. This study aimed to investigate the profile, severity, associations, forms, treatment strategies, and quality of life in psoriasis patients in Oran, Algeria. Data were retrospectively collected over seven years (2016-2022) from two dermatology departments in Oran. Data analysis was performed using IBM SPSS Statistics 20. From 282 patients, 55.3% were female, with disease onset primarily between 18-30 years. Psoriasis was more common in urban residents (83.7%). High blood pressure (16.2%) was the most frequent comorbidity, and 24.2% had a family history of psoriasis. Psychological stress was a triggering factor in 58.9% of cases. Psoriasis vulgaris was most prevalent (70.2%). Topical treatments were the most common (57.4%). The severity index was moderate (10.9±0.40), with a moderate to severe impact on quality of life (11.3±0.48). PASI correlated with family history of autoimmune/metabolic diseases (P=0.046; P=0.043), comorbidities like diabetes and hypertension (P=0.000), and lifestyle factors (P=0.000). PASI was strongly correlated with the quality of life (P=0.000, r=0.604) and inflammation markers (CRP, ESR).Psoriasis significantly influence health, affecting both genders and various age groups. Its etiology and development of comorbidities remain poorly defined.