Radiolucent lesions of the jaw can occur in various forms. These lesions may represent anatomical variations or inflammatory, benign to malignant lesion processes. The disease is a squamous cell carcinoma that arises in the jaw and develops from remnants of odontogenic epithelium, cysts, or pre-existing odontogenic tumors. This case report aims to describe the appearance of aggressive osteolytic lesions in the jaw on panoramic imaging. A 55-year-old female complained of enlargement in the mandibular gingival area and pain on chewing for ±1 month. Initially, ± 2 months after tooth extraction, a pea-sized enlargement appeared in the patient's mouth. There is no history of salty fluid in the patient's mouth. As the size increased, the patient took the initiative to go to the community health center and was referred to the Dental Hospital for a panoramic radiograph. The mandibular ramus was preserved until the lesion destroyed the right condyle. General anesthesia, debridement, incisional biopsy, control of bleeding and washing of the surgical area, then treatment of the open surgical wound and covering it with a bandage. A panoramic radiograph is the only support to see the characteristics of lesion expansion and is considered sufficient as a reference for patient management. However, histopathologic examination is still required for definitive diagnosis.