Aceclofenac is a BCS Class II drug possessing low solubility and high permeability. It belongs to NSAIDs category and is used in the treatment of pain and inflammation caused due to osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The bioavailability of Aceclofenac is found to be poor, limiting its use for oral administration. In order to overcome this, the present study aimed at formulating a matrix type transdermal patch of Aceclofenac using solvent casting method. This will not only enhance the drug delivery of Aceclofenac transdermally but also, facilitate patient compliance due to its ease of application. To achieve these objectives, a transdermal therapeutic system containing Aceclofenac with different ratios of hydrophilic polymers in combination (Eudragit RS100, PEG 400) were prepared using solvent casting method. These prepared transdermal patches were evaluated for parameters like thickness, weight variation, folding endurance, drug content and in vitro drug release. The formulation batches were optimized using 32 factorial designs, from the results obtained A5 formulation was found to be optimized formulation.