Background: Genital prolapse (GP) is a complex dynamic process that has a progressive course, accompanied by the development of structural and functional disorders in the body, often of a destructive nature. The relevance of the problem of genital prolapse is due to its prevalence, early manifestation and high frequency of relapses. Purpose: A comprehensive study of the relationship between clinical and genetic aspects of the development of prolapse and dysfunction of the pelvic organs, prognosis, timely prevention and improvement of the quality of life of women. Methods: The clinical section of the work was carried out on the basis of the Department of Obstetrics and Gynecology, Faculty of Medicine, Bukhara Medical University named after Abu Ali Ibn Sina, and genetic studies were carried out in the laboratory of the Institute of Genetics. Conclusion: For women at risk for the development of genital prolapse with cervical injuries, it is recommended to determine the matrix proteins FBLN-5 and MMP-9 with additional genetic testing to determine further management tactics.