An effective, simple and sensitive analytical method has been developed employing liquid chromatography coupled with tandem mass spectrometry and validated for estimation of 5 carbamate pesticides at trace levels in 3 fruits and 4 vegetables. Plackett-Burman design and central composite design was used to screen and optimize the significant factors in modified QuEChERS (quick, easy, cheap, effective, rugged and safe) extraction method. The method evaluation was done by matrix-matched calibration with linearity ranging from 3 to 500µg/L with a correlation coefficient more than 0.991. The detection and quantification limit ranged from 1µg/kg and 3 to 5 µg/kg, respectively. The mean recoveries were in the range of 78.98-109.64% with the relative standard deviation less than 12.62% for all pesticides. Further, the method developed was applied to analyze real samples cultivated in the plain areas of Tiruppur, Tamil nadu