ISSN : 2663-2187
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Can Combination Therapy Improve Outcomes in PDE5i-Refractory Erectile Dysfunction? A Systematic Review of Low-Intensity Extracorporeal Shockwave Therapy
Volume 8 | Issue - 8
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Influence of Storage Temperature on the Bond Performance of Universal Adhesives: A Narrative Review
Volume 8 | Issue - 8
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Effects of direct acting antivirals(DAAs)on cryoglobulinemia in patients infected with hepatitis C virus
Volume 8 | Issue - 8
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Effect of Education Sessions About Plastic Usage Hazards and Its Safe Disposal on Knowledge and Reported Practice of Female Employees at Port Said University: A Pre–Post Intervention Study
Volume 8 | Issue - 7
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Soil Quality Under a Cocoa-Based Agroforestry System With Associated Indigenous Tree Species In The Department Of Divo (Cote d’Ivoire)
Volume 8 | Issue - 7
Molecular Docking Studies Of Benzothiazole Based Schiff Base Derivatives Against Adenosine A2a Receptor As Potential Anti Parkinsonian Agents
Main Article Content
Abstract
In recent years, Parkinson's disease (PD) has become a major health concern, especially for adults. Parkinson disease is the most prevalent neurological movement disorder. It was shown that all adenosine A2A receptor antagonists have antiparkinsonian effects. Several Schiff-based compounds based on benzothiazoles were created in the current work and their anti-parkinsonian activity was assessed by docking them against the adenosine A2A receptor (pdb id:5UIG). All adenosine A2A receptor antagonists, including Theophylline and Istradefylline, have been demonstrated to have antiparkinsonian properties.
