The implantation process in mammalian reproduction involves complex interactions between the developing embryo and the maternal endometrium. Leukemia Inhibitory Factor (LIF) has emerged as a crucial regulator in this intricate interplay. This review explores the multifaceted roles of LIF genes in implantation processes, revealing insights into its significance in successful pregnancy outcomes. Key findings highlight the impact of LIF gene polymorphism, gene expression patterns, and LIF receptor complexes on the efficiency of embryo implantation. The genetic variant LIF SNP T/G (rs929271) is being recognized as a promising biomarker that could forecast the success of implantation and the outcome of pregnancy, opening avenues for potential therapeutic interventions. Variations in LIF concentrations during menstrual cycle stages highlight its crucial role in implantation, particularly between fertile and infertile women. This study underscores the significance of LIF in fertility mechanisms