Background : Perio-endo lesions are lesions caused by inflammatory products that found in periodontal tissue and pulp at the same time. A comprehensive examination including clinical examination and radiographs will help to get a correct diagnosis. In this case report, regenerative periodontal theraphy with bone graft and membran was performed as a periodontal treatment accompanied by endodontic treatment before making a denture. Objective : This case report was written with the aim of understanding the multidisciplinary care of a patient with perio-endo lesions. Case report : A 42-year-old female patient referred from the prosthodontics department of UNHAS Makassar Dental Hospital came with complaints of loose front upper teeth and often swollen and festering gums. On clinical examination, it was seen the teeth 21,22,23 were mobile grade 2 with the pocket depth of > 5 mm. Radiographic examination showed a radiolucent picture on the apical to lateral teeth 21,22,23. The patient has no history of systemic disease, does not smoke, and does not taking any medications.. The management of this case at the first visit is doing the initial therapy such as of skeling-root planning and radiographic examination. At the second visit, the regenerative periodontal theraphy with bone graft and membran was performed, and then followed by endodontic treatment. GTSL overdenture was made at the final stage of treatment.. Conclusion: Multidisciplinary treatment in this case of perio-endo lesion provides better and satisfactory results for the patient.