Background:TheexpandingroleofNursePractitionersincriticalcaresettingshasbeensignificant in addressing workforce demands and improving patient outcomes. This SystematicReview aims to generate existing evidence about the role, effectiveness or impact and outcomesof Nurse Practitioners in Critical Care. Materials and Methods: A comprehensive search wasdone in various databases like Google Scholar, Pubmed, MEDLINE, CINAHL and CochraneLibrarytillJune2024.Thestudieswereincludediftheyevaluatedtherole,effectivenessorimpactand outcomes of the Nurse Practitioners in Critical Care. The data was extracted and carefullyscrutinized for quality by two reviewers before its inclusion in the review. The quality of theincludedstudieswasassessedusingNewcastle-OttawascaleandRoB2.Results:Atotalofsevenstudies were found eligible. The overall methodological quality of the studies ranged from fair togood. The studies were conducted in different critical care settings. The studies comprised ofRandomized controlled trials, Cohort Study, Comparative designs, Comprehensive Reviews andMixed Designs. Conclusion: Nurse Practitioners play a vital role in the Critical care settings significantly impacting patient outcomes and efficiency of healthcare delivery.