Nutrient deficits and health problems are the main focus of nutrition study at the moment. Healthy diet and genetics have a significant impact in the development of chronic illnesses as cancer, osteoporosis, diabetes and cardiovascular disease. To better understand the impact of diet on health, researchers are using high-throughput ‘omics’ technologies including transcriptomics, proteomic, and metabolomic methods to study the relationship between nutrition and disease. ‘Pharmacogenomics’ studies how a patient responds to medicine, while ‘nutrigenomics’ examines the influence of nutrients and dietary components on an individual's health. With the goal of providing a comprehensive summary of the nutrigenomics change from nutraceuticals, this review paper presents current tactics, future possibilities and problems.