This study looks into whether nanostructured lipid carriers could be used as an oral preparation to make TZN work better as a medicine. To create TZN-loaded NLCs, the solvent evaporation method called for the employment of solid glyceryl monostearate lipids and liquid oleic acid lipids. Tween 80 and poloxamer 188 were combined to serve as surfactants. Entrapment efficiency and particle size were the primary response criteria utilized in the Box-Behnken design to determine the optimal formulation. The modified blend was evaluated for morphological studies, drug release properties, zeta potential, particle size, polydispersity index, and drug passage/trap efficiency. In in vitro release tests, the NLCs showed significant drug release profiles. This shows that they could be used for better drug delivery with longer release profiles. Based on the results shown above, it looks like the current optimization process can be used to make NLCs that have the right pharmacological qualities. This system might be able to provide a safer and more effective way to deliver TZN in medicines. The study's goal was to improve the therapeutic outcomes and general effectiveness of tizanidine.