Pharmacist play a pivotal role in offering counselling service to patient with chronic diseases. The objective is to enhance understanding of patient’s condition and manage that by promoting adherence of prescribed medications. A prospective interventional study was conducted in a multi-centric tertiary care hospital in south Gujarat from November 2021 to April 2022 with the purpose of evaluating the effectiveness of clinical pharmacy-mediated patient counselling for people with diabetes and hypertension. A total of 107 patients were participated in this study, and their Knowledge, Attitude, and Practice (KAP) were evaluated using KAP survey Questionnaires. Medication Adherence was also assessed using Morisky Medication Adherence Scale (MMAS-4).The results of this study revealed a significant improvement in patient’s Knowledge, Attitude, and Practice after receiving counselling. Furthermore, there was a remarkable improvement in Medication Adherence levels. This intervention led to significant improvements in Blood Sugar and Blood Pressure levels.This study exhibits the substantial impact of clinical pharmacist-mediated counselling service on patient’s Knowledge, Attitude, and Practice and Medication Adherence in patients having Diabetes with Hypertension. The findings strongly support the incorporation of pharmacist led counselling service into healthcare strategies to achieve definite and improved outcomes in various clinical settings